When the serum E 2 level was greater than 300 pg/mL, the clinical pregnancy rate decreased significantly (62.9% vs. Further smooth fitting curve analysis was employed by different subgroups segmented according to different endometrial thicknesses. The clinical pregnancy and miscarriage rates of all groups were compared. In addition, patients were divided into 2 groups based on their levels of serum E 2 measured before progesterone-induced endometrial transformation: Group 1, < 300 pg/mL ( n = 6251) and Group 2, ≥ 300 pg/mL ( n = 3958). Then, threshold and saturation effect analysis was employed to explore the cut-off value of serum E 2 levels.
A smooth fitting curve was constructed to identify the relationship between serum E 2 levels before endometrial transformation and the clinical pregnancy rate. This study aimed to explore the relationship between serum oestrogen (E 2 ) levels before endometrial transformation and pregnancy outcomes of hormone replacement therapy-frozen embryo transfer (HRT-FET) cycles, which has been investigated for years without any consensus.Ī retrospective cohort study of 10,209 cycles HRT-FET cycles was conducted at the Reproductive Medicine Center of Nanjing Drum Tower Hospital from March 2017 to December 2020. The serum estradiol level did not predict pregnancy success in hormone replacement FET cycles, suggesting that oestradiol monitoring in this method of endometrial preparation is unnecessary. Patients with different levels of serum oestradiol (percentile 0-25th, 25th-75th and 75th-100th) on progesterone initiation day yielded the endometrium thickness of 9.3 +/- 0.12, 8.9 +/- 0.07 and 9.1 +/- 0.11 mm(P > 0.05) and the pregnancy rate of 32.2%, 38.4% and 36.3% (P > 0.05) respectively. They were detected of serum oestradiol levels and endometrium thicknesses during hormone supplement FET cycles and compared their pregnancy outcomes according to their oestradiol level on progesterone initiation day. The data from two hundred twelve women undergoing two hundred seventy-four frozen-thawed embryo transfer (FET) cycles was included in this retrospective cohort study. To discuss the meaning of serum oestradiol monitoring in frozen embryo transfer cycle using hormone replacement without pretreatment with gonadotropin hormone (GnRH) agonist.
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